Pre-formulation, Material
Characterization
This constitutes the 1st few phases of drug product development and involves the
establishment of pertinent physico-chemical, mechanical and biological
properties. Proper pre-formulation studies can facilitate subsequent process
optimization and exploration of novel product lines. As pre-formulation studies
are often laborious and costly, we are continually developing better tools to
expedite this process and predict the performance in their respective unit
operations.
Particle
Engineering
Particle engineering and surface modification of starting materials are useful
to improve morphological presentations and physico-mechanical properties. These
techniques help to overcome common problems that arise in downstream
pharmaceutical unit operations, particularly, hopper flow, particle/granule
coating, compaction and milling behavior. Additionally, we are investigating the
design of porous particles to serve as carriers for drug powder inhalers.
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