The number of research publications and conferences papers from GEA-NUS PPRL has increased significantly in quantity as well as quality. As we gain international recognition for our work, we have consistently attracted a pool of creative, hardworking and energetic individuals all over the world to share our passion for pharmaceutical technology and pharmaceutics.
Publications in the last 10 years
1.
Saw, C.L.L., Olivo, M., Soo, K.C., and Heng, P.W.S., Use of hypericin in
photodynamic applications. Recent progress in medicinal plants, ed. J.N. Govil.
Vol. 20. in press, New Delhi: Studium Press LLC.
2.
Saw, C.L.L. and Heng, P.W.S., Hypericin. 2nd ed. Cancer Encyclopedia, ed.
M. Schwab. in press: Springer.
3.
Saw, C.L.L, Heng, P., and M, O., Potentiation of the photodynamic action
of hypericin. J Environ Pathol Toxicol Oncol, in press.
4.
Tan, L.H.e.a., Process analytical technology: application to particle
sizing in spray drying. AAPS PharmSciTech, accepted 19 Sep 2007.
5.
Tang, E.S., Wang, L., Liew, C.V., Chan, L.W., and Heng, P.W.S., Drying
efficiency and particle movement in coating-Impact on particle agglomeration and
yield. Int J Pharm, 2007.
6.
Tang, E.S., Liew, C.V., Er, D.Z., Liu, X., Wigmore, A.J., and Heng,
P.W.S., Study of coat quality of tablets coated by an on-line Supercell coater.
AAPS PharmSciTech, 2007. 8(3): p. E63.
7.
Saw, C.L.L., Olivo, M., Wohland, T., Fu, C.Y., Kho, K.W., Soo, K.C., and
Sia Heng, P.W.S., Effects of N-methyl pyrrolidone on the uptake of hypericin in
human bladder carcinoma and co-staining with DAPI investigated by confocal
microscopy. Technol Cancer Res Treat, 2007. 6(5): p. 383-94.
8.
Saw, C.L.L., Olivo, M., Chin, W.W., Soo, K.C., and Heng, P.W.S.,
Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence
diagnosis of human bladder cancer cells implanted in the chick chorioallantoic
membrane model. J Photochem Photobiol B, 2007. 86(3): p. 207-18.
9.
Liew, C.V., Chua, S.M., and Heng, P.W.S., Elucidation of spheroid
formation with and without the extrusion step. AAPS PharmSciTech, 2007. 8(1): p.
10.
10. Chow, K.T., Chan, L.W.,
and Heng, P.W.S., Formulation of hydrophilic non-aqueous gel: drug stability in
different solvents and rheological behavior of gel matrices. Pharm Res, 2007.
11. Chow, K.T., Chan, L.W.,
and Heng, P.W.S., Characterization of spreadability of nonaqueous ethylcellulose
gel matrices using dynamic contact angle. J Pharm Sci, 2007.
12. Chin, W.W., Lau, W.K.,
Bhuvaneswari, R., Heng, P.W.S., and Olivo, M., Chlorin e6-polyvinylpyrrolidone
as a fluorescent marker for fluorescence diagnosis of human bladder cancer
implanted on the chick chorioallantoic membrane model. Cancer Lett, 2007.
245(1-2): p. 127-33.
13. Cheong, W.S., Heng,
P.W.S., and Wong, T.W., Impact of a non-meltable additive on melt agglomeration
with a hydrophobic meltable binder in high-shear mixer. Pharm Dev Technol, 2007.
12(4): p. 371-80.
14. Chan, L.W., Zhou, Q., and
Heng, P.W.S., Comparison of surface roughness parameters obtained by scanning
probe microscopy for carrier particles of dry powder inhalers. Journal of Drug
Delivery Science and Technology, 2007. 17(3): p. 217-222.
15. Chan, L.W., Ching, A.L.,
Liew, C.V., and Heng, P.W.S., Mechanistic study on hydration and drug release
behavior of sodium alginate compacts. Drug Dev Ind Pharm, 2007. 33(6): p.
667-76.
16. Soh, J.L., Liew, C.V., and
Heng, P.W.S., New indices to characterize powder flow based on their avalanching
behavior. Pharm Dev Technol, 2006. 11(1): p. 93-102.
17. Soh, J.L., Liew, C.V., and
Heng, P.W.S., Torque rheological parameters to predict pellet quality in
extrusion-spheronization. Int J Pharm, 2006. 315(1-2): p. 99-109.
18. Saw, C.L.L/, Olivo, M.,
Soo, K.C., and Heng, P.W.S., Delivery of hypericin for photodynamic
applications. Cancer Lett, 2006. 241(1): p. 23-30.
19. Saw, C.L.L., Olivo, M.,
Soo, K.C., and Heng, P.W.S., Spectroscopic characterization and photobleaching
kinetics of hypericin-N-methyl pyrrolidone formulations. Photochem Photobiol Sci,
2006. 5(11): p. 1018-23.
20. Saw, C.L.L., Heng, P.W.S.,
Chin, W.W., Soo, K.C., and Olivo, M., Enhanced photodynamic activity of
hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick
chorioallantoic membrane model. Cancer Lett, 2006. 238(1): p. 104-10.
21. Nair, S., Xu, C., Shen,
G., Hebbar, V., Gopalakrishnan, A., Hu, R., Jain, M.R., Lin, W., Keum, Y.S.,
Liew, C., Chan, J.Y., and Kong, A.N., Pharmacogenomics of phenolic antioxidant
butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout
and C57BL/6J mice. Pharm Res, 2006. 23(11): p. 2621-37.
22. Manivasager, V., Yee,
K.K., Heng, P.W.S., Soo, K.C., and Olivo, M., A study comparing endogenous
protoporphyrin IX induced by 5-ALA and ALA-methyl ester with exogenous PpIX and
PpIX dimethyl ester in photodynamic diagnosis of human nasopharyngeal carcinoma
xenografts. Int J Oncol, 2006. 29(4): p. 997-1002.
23. Liu, X., Heng, W.S., Paul,
Li, Q., and Chan, L.W., Novel polymeric microspheres containing norcantharidin
for chemoembolization. J Control Release, 2006. 116(1): p. 35-41.
24. Liew, C.V., Chan, L.W.,
Ching, A.L., and Heng, P.W.S., Evaluation of sodium alginate as drug release
modifier in matrix tablets. Int J Pharm, 2006. 309(1-2): p. 25-37.
25. Lee, H.Y., Chan, L.W.,
Dolzhenko, A.V., and Heng, P.W.S., Influence of viscosity and uronic acid
composition of alginates on the properties of alginate films and microspheres
produced by emulsification. J Microencapsul, 2006. 23(8): p. 912-27.
26. Keum, Y.S., Han, Y.H.,
Liew, C., Kim, J.H., Xu, C., Yuan, X., Shakarjian, M.P., Chong, S., and Kong,
A.N., Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1
(NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its
metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat
hepatocytes. Pharm Res, 2006. 23(11): p. 2586-94.
27. Heng, P.W.S., Chan, L.W.,
and Tang, E.S., Use of swirling airflow to enhance coating performance of bottom
spray fluid bed coaters. Int J Pharm, 2006. 327(1-2): p. 26-35.
28. Gu, L., Liew, C.V., Soh,
J.L., and Heng, P.W.S., Feasibility of eliminating premixing for the production
of pellets in a rotary processor. Pharm Dev Technol, 2006. 11(2): p. 159-65.
29. Chin, W.W., Lau, W.K.,
Heng, P.W.S., Bhuvaneswari, R., and Olivo, M., Fluorescence imaging and
phototoxicity effects of new formulation of chlorin e6-polyvinylpyrrolidone. J
Photochem Photobiol B, 2006. 84(2): p. 103-10.
30. Chin, W.W., Heng, P.W.S.,
Bhuvaneswari, R., Lau, W.K., and Olivo, M., The potential application of chlorin
e6-polyvinylpyrrolidone formulation in photodynamic therapy. Photochem Photobiol
Sci, 2006. 5(11): p. 1031-7.
31. Cheah, E.L.L., Chan, L.W.,
and Heng, P.W.S., Supercritical carbon dioxide and its application in the
extraction of active principles from plant materials. Asian Journal of
Pharmaceutical Sciences, 2006. 1(1): p. 59-71.
32. Chan, L.W., Tang, E.S.,
and Heng, P.W.S., Comparative study of the fluid dynamics of bottom spray fluid
bed coaters. AAPS PharmSciTech, 2006. 7(2): p. E37.
33. Chan, L.W., Lee, H.Y., and
Heng, P.W.S., Mechanisms of external and internal gelation and their impact on
the functions of alginate as a coat and delivery system. Carbohydrate Polymers,
2006. 63(2): p. 176-187.
34. Chan, L.W., Chow, K.T.,
and Heng, P.W.S., Investigation of wetting behavior of nonaqueous ethylcellulose
gel matrices using dynamic contact angle. Pharm Res, 2006. 23(2): p. 408-21.
35. Wu, J.Y., Liu, S.Q., Heng,
P.W.S., and Yang, Y.Y., Evaluating proteins release from, and their interactions
with, thermosensitive poly (N-isopropylacrylamide) hydrogels. J Control Release,
2005. 102(2): p. 361-72.
36. Wong, T.W., Cheong, W.S.,
and Heng, P.W.S., Metl granulation and pelletization. 2nd ed. Handbook of
pharmaceutical granulation technology, ed. D.M. Parikh. 2005, Roca Raton,
Florida: Taylor & Francis. 385-406.
37. Wong, T.W., Chan, L.W.,
Kho, S.B., and Heng, P.W.S., Aging and microwave effects on alginate/chitosan
matrices. J Control Release, 2005. 104(3): p. 461-75.
38. Wang, M.Y., Yang, Y.Y.,
and Heng, P.W.S., Skin permeation of physostigmine from fatty acids-based
formulations: evaluating the choice of solvent. Int J Pharm, 2005. 290(1-2): p.
25-36.
39. Tang, E.S., Chan, L.W.,
and Heng, P.W.S., Coating of multiparticulates for sustained release. American
Journal of Drug Delivery, 2005. 3(1): p. 17-28.
40. Tan, L.H., Chan, L.W., and
Heng, P.W.S., Effect of oil loading on microspheres produced by spray drying. J
Microencapsul, 2005. 22(3): p. 253-9.
41. Saw, C.L.L, Olivo, M.,
Chin, W.W., Soo, K.C., and Heng, P.W.S., Transport of hypericin across chick
chorioallantoic membrane and photodynamic therapy vasculature assessment. Biol
Pharm Bull, 2005. 28(6): p. 1054-60.
42. Liew, C.V., Soh, J.L.,
Chen, F., Shi, D., and Heng, P.W.S., Application of multidimensional scaling to
preformulation sciences: a discriminatory tool to group microcrystalline
celluloses. Chem Pharm Bull (Tokyo), 2005. 53(10): p. 1227-31.
43. Liew, C.V., Gu, L., Soh,
J.L., and Heng, P.W.S., Functionality of cross-linked polyvinylpyrrolidone as a
spheronization aid: a promising alternative to microcrystalline cellulose. Pharm
Res, 2005. 22(8): p. 1387-98.
44. Lee, H.Y., Chan, L.W., and
Heng, P.W.S., Influence of partially cross-linked alginate used in the
production of alginate microspheres by emulsification. J Microencapsul, 2005.
22(3): p. 275-80.
45. Heng, P.W.S., Yolande, A.,
and Lee, C.C., Rapid release granulation. 2nd ed. Handbook of pharmaceutical
granulation technology, ed. D.M. Parikh. 2005, Roca Raton, Florida: Taylor &
Francis. 407-429.
46. Heng, P.W.S., Chan, L.W.,
and Chow, K.T., Development of novel nonaqueous ethylcellulose gel matrices:
rheological and mechanical characterization. Pharm Res, 2005. 22(4): p. 676-84.
47. Guo, Q.Y., Chan, L.W., and
Heng, P.W.S., Investigation of the release of aspirin from spray-congealed
micro-pellets. J Microencapsul, 2005. 22(3): p. 245-51.
48. Chee, S.N., Johansen,
A.L., Gu, L., Karlsen, J., and Heng, P.W.S., Microwave drying of granules
containing a moisture-sensitive drug: a promising alternative to fluid bed and
hot air oven drying. Chem Pharm Bull (Tokyo), 2005. 53(7): p. 770-5.
49. Chan, L.W., Ong, K.T., and
Heng, P.W.S., Novel film modifiers to alter the physical properties of composite
ethylcellulose films. Pharm Res, 2005. 22(3): p. 476-89.
50. Chan, L.W., Liu, X., and
Heng, P.W.S., Liquid phase coating to produce controlled-release alginate
microspheres. J Microencapsul, 2005. 22(8): p. 891-900.
51. Chan, L.W. and Heng,
P.W.S., Drug substance and excipient characterization. 2nd ed. Handbook of
pharmaceutical granulation technology, ed. D.M. Parikh. 2005, Roca Raton,
Florida: Taylor & Francis. 79-107.
52. Wang, M.Y., Yang, Y.Y.,
and Heng, P.W.S., Role of solvent in interactions between fatty acids-based
formulations and lipids in porcine stratum corneum. J Control Release, 2004.
94(1): p. 207-16.
53. Tammilmani, V., Yee, K.K.,
Heng, P.W.S., Soo, K.C., and Olivo, M., An evaluation of exogenous application
of protoporphyrin IX and its dimethyl ester as a photodynamic diagnostic agent
in poorly differentiated human nasopharyngeal carcinoma. Photochem Photobiol,
2004. 80(3): p. 596-601.
54. Soh, J.L., Chen, F., Liew, C.V.,
Shi, D., and Heng, P.W.S., A novel preformulation tool to group microcrystalline
celluloses using artificial neural network and data clustering. Pharm Res, 2004.
21(12): p. 2360-8.
55. Kwok, T.S., Sunderland,
B.V., and Heng, P.W.S., An investigation on the influence of a vinyl pyrrolidone/vinyl
acetate copolymer on the moisture permeation, mechanical and adhesive properties
of aqueous-based hydroxypropyl methylcellulose film coatings. Chem Pharm Bull
(Tokyo), 2004. 52(7): p. 790-6.
56. Heng, P.W.S., Liew, C.V.,
and Soh, J.L., Pre-formulation studies on moisture absorption in
microcrystalline cellulose using differential thermo-gravimetric analysis. Chem
Pharm Bull (Tokyo), 2004. 52(4): p. 384-90.
57. Heng, P.W.S., Hao, J.,
Chan, L.W., and Chew, S.H., Influences of osmotic agents in diffusion layer on
drug release from multilayer coated pellets. Drug Dev Ind Pharm, 2004. 30(2): p.
213-20.
58. Heng, P.W.S., Chan, L.W.,
Liew, C.V., Chee, S.N., Soh, J.L., and Ooi, S.M., Roller compaction of crude
plant material: influence of process variables, polyvinylpyrrolidone, and
co-milling. Pharm Dev Technol, 2004. 9(2): p. 135-44.
59. Hao, J.S., Chan, L.W.,
Shen, Z.X., and Heng, P.W.S., Complexation between PVP and Gantrez polymer and
its effect on release and bioadhesive properties of the composite PVP/Gantrez
films. Pharm Dev Technol, 2004. 9(4): p. 379-86.
60. Gu, L., Liew, C.V., and
Heng, P.W.S., Wet spheronization by rotary processing--a multistage single-pot
process for producing spheroids. Drug Dev Ind Pharm, 2004. 30(2): p. 111-23.
61. Manivasager, V., Heng,
P.W.S., Hao, J., Zheng, W., Soo, K.C., and Olivo, M., A study of
5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems
of human bladder cancer. Int J Oncol, 2003. 22(2): p. 313-8.
62. Lee, C.C., Chan, L.W., and
Heng, P.W.S., Use of a fluidized bed hammer mill for size reduction and
classification: effects of process variables and starting materials on the
particle size distribution of milled lactose batches. Pharm Dev Technol, 2003.
8(4): p. 431-42.
63. Heng, P.W.S. and Wong,
T.W., Melt processes for oral solid dosage forms. Encyclopedia of Pharmaceutical
Technology-Reprint Program. 2003: 270 Madison Av., New York, (an on-line
publication). 1-6.
64. Heng, P.W.S., Wong, T.W.,
and Cheong, W.S., Investigation of melt agglomeration process with a hydrophobic
binder in combination with sucrose stearate. Eur J Pharm Sci, 2003. 19(5): p.
381-93.
65. Heng, P.W.S., Chan, L.W.,
and Wong, T.W., Formation of alginate microspheres produced using emulsification
technique. J Microencapsul, 2003. 20(3): p. 401-13.
66. Heng, P.W.S., Chan, L.W.,
and Ong, K.T., Influence of storage conditions and type of plasticizers on
ethylcellulose and acrylate films formed from aqueous dispersions. J Pharm Pharm
Sci, 2003. 6(3): p. 334-44.
67. Hao, J. and Heng, P.W.S.,
Buccal delivery systems. Drug Dev Ind Pharm, 2003. 29(8): p. 821-32.
68. Chan, L.W., Wong, T.W.,
Chua, P.C., York, P., and Heng, P.W.S., Anti-tack action of polyvinylpyrrolidone
on hydroxypropylmethylcellulose solution. Chem Pharm Bull (Tokyo), 2003. 51(2):
p. 107-12.
69. Chan, L.W., Lim, L.T., and
Heng, P.W.S., Immobilization of fine particles on lactose carrier by precision
coating and its effect on the performance of dry powder formulations. J Pharm
Sci, 2003. 92(5): p. 975-84.
70. Wong, T.W., Heng, P.W.S.,
Yeo, T.N., and Chan, L.W., Influence of polyvinylpyrrolidone on aggregation
propensity of coated spheroids. Int J Pharm, 2002. 242(1-2): p. 357-60.
71. Wong, T.W., Chan, L.W.,
Lee, H.Y., and Heng, P.W.S., Release characteristics of pectin microspheres
prepared by an emulsification technique. J Microencapsul, 2002. 19(4): p.
511-22.
72. Wong, T.W., Chan, L.W.,
Kho, S.B., and Heng, P.W.S., Design of controlled-release solid dosage forms of
alginate and chitosan using microwave. J Control Release, 2002. 84(3): p.
99-114.
73. Wong, T., Lee, H., Chan, L., and
Heng, P., Drug release properties of pectinate microspheres prepared by
emulsification method. Int J Pharm, 2002. 242(1-2): p. 233-7.
74. Manivasager, V., Heng,
P.W.S., Hao, J., Zheng, W., Soo, K.C., and Olivo, M., Macro-microscopic
fluorescence imaging of human NPC xenografts in a murine model using topical vs
intravenous administration of 5-aminolevulinic acid. Int J Oncol, 2002. 21(5):
p. 1003-7.
75. Liew, C., Gu, L., and
Heng, P., The influence of operational variables on mean size and size
distribution of spheroids produced by rotary spheronization using teardrop
studs. Int J Pharm, 2002. 242(1-2): p. 345-8.
76. Heng, P.W.S. and
Easterbrook, M., Tablet coating technology. European Pharmaceutical Review,
2002. 7(3): p. 44-47.
77. Heng, P.W.S., Liew, C.V.,
and Gu, L., Influence of teardrop studs on rotating frictional base plate on
spheroid quality in rotary spheronization. Int J Pharm, 2002. 241(1): p. 173-84.
78. Chan, L.W., Lee, H.Y., and
Heng, P.W.S., Production of alginate microspheres by internal gelation using an
emulsification method. Int J Pharm, 2002. 242(1-2): p. 259-62.
79. Chan, L.W., Lee, C.C., and
Heng, P.W.S., Ultrafine grinding using a fluidized bed opposed jet mill: effects
of feed load and rotational speed of classifier wheel on particle shape. Drug
Dev Ind Pharm, 2002. 28(8): p. 939-47.
80. Chan, L.W., Jin, Y., and
Heng, P.W.S., Cross-linking mechanisms of calcium and zinc in production of
alginate microspheres. Int J Pharm, 2002. 242(1-2): p. 255-8.
81. Chan, L.W. and Heng,
P.W.S., Effects of aldehydes and methods of cross-linking on properties of
calcium alginate microspheres prepared by emulsification. Biomaterials, 2002.
23(5): p. 1319-26.
82. Koo, O.M. and Heng,
P.W.S., The influence of microcrystalline cellulose grade on shape and shape
distributions of pellets produced by extrusion-spheronization. Chem Pharm Bull
(Tokyo), 2001. 49(11): p. 1383-7.
83. Heng, P.W.S. and Koo,
O.M., A study of the effects of the physical characteristics of microcrystalline
cellulose on performance in extrusion spheronization. Pharm Res, 2001. 18(4): p.
480-7.
84. Heng, P.W.S., Chan, L.W.,
Easterbrook, M.G., and Li, X., Investigation of the influence of mean HPMC
particle size and number of polymer particles on the release of aspirin from
swellable hydrophilic matrix tablets. J Control Release, 2001. 76(1-2): p.
39-49.
85. Chan, L.W., Chan, W.Y.,
and Heng, P.W.S., An improved method for the measurement of colour uniformity in
pellet coating. Int J Pharm, 2001. 213(1-2): p. 63-74.
86. Wong, T.W., Chan, L.W.,
and Heng, P.W.S., Study of the melt pelletization process focusing on the
micromeritic property of pellets. Chem Pharm Bull (Tokyo), 2000. 48(11): p.
1639-43.
87. Sim, K.M., Boey, S.K.,
Heng, P.W.S., and Chan, Y.W., Total intravenous anaesthesia using 3-in-1 mixture
of propofol, alfentanil and mivacurium. Ann Acad Med Singapore, 2000. 29(2): p.
182-8.
88. Liew, C.V., Wan, L.S., and
Heng, P.W.S., Role of base plate rotational speed in controlling spheroid size
distribution and minimizing oversize particle formation during spheroid
production by rotary processing. Drug Dev Ind Pharm, 2000. 26(9): p. 953-63.
89. Heng, P.W.S., Chan, L.W.,
and Zhu, L., Effects of process variables and their interactions of melt
pelletization in high shear mixer. Sciences Techniques Pharmaceutische Pharma
Sciences, 2000. 10(2): p. 165-172.
90. Heng, P.W.S., Chan, L.W.,
and Lee, C.C., Ultrafine grinding using a fluidised bed opposed jet mill:
effects of process parameters on the size distribution of milled particles.
Sciences Techniques Pharmaceutische Pharma Sciences, 2000. 10(1): p. 445-451.
91. Heng, P.W.S., Wong, T.W.,
and Chan, L.W., Influence of production variables on the sphericity of melt
pellets. Chem Pharm Bull (Tokyo), 2000. 48(3): p. 420-4.
92. Heng, P.W.S., Chan, L.W.,
and Lim, L.T., Quantification of the surface morphologies of lactose carriers
and their effect on the in vitro deposition of salbutamol sulphate. Chem Pharm
Bull (Tokyo), 2000. 48(3): p. 393-8.
93. Heng, P.W.S., Chan, L.W.,
Liew, C.V., and Ng, T.Y., Effect of tabletting compaction pressure on alginate
microspheres. J Microencapsul, 2000. 17(5): p. 553-64.
94. Chan, L.W., Lim, L.T., and
Heng, P.W.S., Microencapsulation of oils using sodium alginate. J Microencapsul,
2000. 17(6): p. 757-66.
95. Wong, T.W., Wan, L.S., and
Heng, P.W.S., Effects of physical properties of PEG 6000 on pellets produced by
melt pelletization. Pharm Dev Technol, 1999. 4(3): p. 449-56.
96. Tan, Y.T., Heng, P.W.S.,
and Wan, L.S., Mixed polymer coating for modified release from coated spheroids.
Pharm Dev Technol, 1999. 4(4): p. 561-70.
97. Heng, P.W.S., Wong, T.W.,
Shu, J.J., and Wan, L.S., A new method for the control of size of pellets in
melt pelletization process with a high shear mixer. Chem Pharm Bull (Tokyo),
1999. 47(5): p. 633-638.
98. Heng, P.W.S., Chan, L.W.,
and Chan, W.Y., Application of spot colour measurement for the optimisation of
color coating. Sciences Techniques Pharmaceutische Pharma Sciences, 1999. 9(6):
p. 539-544.
99. Heng, P.W.S., Wong, T.W.,
and Wan, L.S., A probe test method for determination of molten binder tack.
Pharm Dev Technol, 1999. 4(3): p. 457-60.
100. Heng, P.W.S., Wan, L.S., and Wong,
T.W., Effect of off-bottom clearance on properties of pellets produced by melt
pelletization. Pharm Dev Technol, 1999. 4(1): p. 27-33.
101. Heng, P.W.S., Chan, L.W., and Chew,
S.H., Mechanism of pellet coat rupture and its effect on drug release. Chem
Pharm Bull (Tokyo), 1999. 47(7): p. 939-43.
102. Chan, L.W., Hao, J.S., and Heng, P.W.S.,
Evaluation on permeability and mechanical property of composite polyvinyl
alcohol films. Chem Pharm Bull (Tokyo), 1999. 47(10): p. 1412-1216.
103. Wan, L.S., Tan, Y.T.F., and Heng,
P.W.S., Drug release kinetics of bi-layer coated spheroids. Sciences Techniques
Pharmaceutische Pharma Sciences, 1998. 8(2): p. 113-122.
104. Tan, Y.T.F., Wan, L.S., and Heng,
P.W.S., Evaluation of adhesion strength measurement for predicting aggregation
propensity during fluidised bed coating. Sciences Techniques Pharmaceutische
Pharma Sciences, 1998. 8(3): p. 149-153.
105. Liew, C.V., Wan, L.S., and Heng,
P.W.S., Influence of polytetrafluoroethylene on spheroid production by rotary
processing. Sciences Techniques Pharmaceutische Pharma Sciences, 1998. 8(5): p.
297-302.
106. Chan, L.W. and Heng, P.W.S., Effects
of poly(vinylpyrrolidone) and ethylcellulose on alginate microspheres prepared
by emulsification. J Microencapsul, 1998. 15(4): p. 409-20.
107. Wan, L.S., Heng, P.W.S., Chan, L.W.,
Lee, C.C., Ho, E.K., Ngoh, W.K., Lam, T.J., and Waldord, J.J., Effect of feeding
microspheres containing thyroid hormone on larval growth and development on
tilapia and seabass. Journal of Aquaculture in the Tropics, 1997. 12: p.
191-199.
108. Heng, P.W.S. and Chan, L.W., Drug
substance and excipient characterization. Handbook of pharmaceutical granulation
technology, ed. D.M. Parikh. 1997, New York: Mercel Dekker, Inc. 25-57.
109. Chan, L.W., Heng, P.W.S., and Wan,
L.S., Effect of cellulose derivatives on alginate microspheres prepared by
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